Journal Scans
High Id1 Expression Is Associated With Poor Prognosis in 237 Patients With Acute Myeloid Leukemia
High Id1 Expression Indicates Poor Prognosis in AML
R Tang, P Hirsch, F Fava, S Lapusan, C Marzac, I Teyssandier, J Pardo, J-P Marie, O Legrand
20090901
2009 Oct 1
Blood
High Id1 Expression Is Associated With Poor Prognosis in 237 Patients With Acute Myeloid Leukemia
Blood. 2009 Oct 1;114(14):2993-3000, R Tang, P Hirsch, F Fava, S Lapusan, C Marzac, I Teyssandier, J Pardo, J-P Marie, O Legrand
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Abstract
Abstract
Inhibitors of differentiation (Id) are a group of dominant inhibitors of basic helix-loop-helix transcriptional factors, which promote excessive proliferation, and also protect cells against drug-induced apoptosis in mammalians. Recently, Id1 has been identified as a common downstream target of several constitutively activated oncogenic tyrosine kinase, such as FLT3 internal tandem duplication, in leukemia cells. We analyzed Id1 expression as possible prognostic factor in 237 acute myeloid leukemia...
