Journal Scans
Genomic Index of Sensitivity to Endocrine Therapy for Breast Cancer
ER-Related Gene Expression Predicts Response to Therapy
WF Symmans, C Hatzis, C Sotiriou, F Andre, F Peintinger, P Regitnig, G Daxenbichler, C Desmedt, J Domont, C Marth, S Delaloge, T Bauernhofer, V Valero, DJ Booser, GN Hortobagyi, L Pusztai
20100709
2010 Aug 9
J Clin Oncol
Genomic Index of Sensitivity to Endocrine Therapy for Breast Cancer
J Clin Oncol. 2010 Aug 9;[Epub Ahead of Print], WF Symmans, C Hatzis, C Sotiriou, F Andre, F Peintinger, P Regitnig, G Daxenbichler, C Desmedt, J Domont, C Marth, S Delaloge, T Bauernhofer, V Valero, DJ Booser, GN Hortobagyi, L Pusztai
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Abstract
SUMMARY
OncologySTAT Editorial Team
The estrogen receptor (ER) activates transcription of numerous genes. In breast cancer patients, overall gene transcription is principally determined by ER status. Symmans et al hypothesized that measuring the level of ER-associated gene expression in a breast tumor sample would show the extent of ER transcriptional activity and thus its dependence on estrogen stimulation. Such a measurement could predict the intrinsic sensitivity of the tumor to endocrine therapy. Using 437 microarray profiles from...
