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Genomic Changes in Chromosomes 10, 16, and X in Malignant Peripheral Nerve Sheath Tumors Identify a High-Risk Patient Group
Genomic Changes Identify High-risk Malignant Peripheral Nerve Sheath Tumors
HR Brekke, FR Ribeiro, M Kolberg, TH Agesen, GE Lind, M Eknæs, KS Hall, B Bjerkehagen, E van den Berg, MR Teixeira, N Mandahl, S Smeland, F Mertens, RI Skotheim, RA Lothe
20090116
2009 Feb 16
Ann Oncol
Genomic Changes in Chromosomes 10, 16, and X in Malignant Peripheral Nerve Sheath Tumors Identify a High-Risk Patient Group
Ann Oncol. 2009 Feb 16; Epub ahead of print, HR Brekke, FR Ribeiro, M Kolberg, TH Agesen, GE Lind, M Eknæs, KS Hall, B Bjerkehagen, E van den Berg, MR Teixeira, N Mandahl, S Smeland, F Mertens, RI Skotheim, RA Lothe
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Abstract
SUMMARY
OncologySTAT Editorial Team
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive cancers originating from the neuroectoderm. Half of these rare tumors arise from plexiform neurofibromas that are present in patients with neurofibromatosis type 1 (NF1). Although karyotypes of these patients tend to be complex, the effect of genetic aberrations on clinical outcomes is not well understood. A better understanding of the effects of chromosomal changes in patients with MPNSTs would be beneficial in terms of improving diagnosis...
