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Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer
BRCAness Profile Is Independently Prognostic in Epithelial Ovarian Cancer
PA Konstantinopoulos, D Spentzos, BY Karlan, T Taniguchi, E Fountzilas, N Francoeur, DA Levine, SA Cannistra
20100514
2010 Jun 14
J Clin Oncol
Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer
J Clin Oncol. 2010 Jun 14;[Epub Ahead of Print], PA Konstantinopoulos, D Spentzos, BY Karlan, T Taniguchi, E Fountzilas, N Francoeur, DA Levine, SA Cannistra
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Abstract
SUMMARY
OncologySTAT Editorial Team
In ovarian cancer, germline mutations of the BRCA1 and BRCA2 genes are associated with defective homologous recombination (HR), a key mechanism of repair of double-stranded DNA. Defective HR may be associated with sensitivity to platinum-containing chemotherapy. Impaired HR has also been shown to interrupt the base excision repair pathway, which is targeted by poly-ADP ribose polymerase (PARP) inhibition, a promising therapeutic mechanism for treating BRCA-mutant ovarian cancer. Although only about...
