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Expression of Estrogen Receptor Beta Predicts a Clinical Response and Longer Progression-Free Survival After Treatment With EGFR–TKI for Adenocarcinoma of the Lung
ER Beta Correlates With Lung Cancer Response to EGFR–TKI
N Nose, H Uramoto, T Iwata, T Hanagiri, K Yasumoto
20100608
2010 Jul 8
Lung Cancer
Expression of Estrogen Receptor Beta Predicts a Clinical Response and Longer Progression-Free Survival After Treatment With EGFR–TKI for Adenocarcinoma of the Lung
Lung Cancer. 2010 Jul 8;[Epub Ahead of Print], N Nose, H Uramoto, T Iwata, T Hanagiri, K Yasumoto
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Abstract
Abstract
Purpose: Epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (EGFR–TKI) demonstrates a dramatic clinical response for the lung adenocarcinoma patients harboring a somatic mutation of EGFR. Such EGFR mutations are frequently found in adenocarcinoma with a strong expression of estrogen receptor (ER) beta, which has been shown to correlate with a favorable prognosis for the patients with EGFR mutations. The aim of this study is to elucidate the correlation between expression of ER beta...
