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Effect of the Gonadotropin-Releasing Hormone Analogue Triptorelin on the Occurrence of Chemotherapy-Induced Early Menopause in P remenopausal Women With Breast Cancer
Triptorelin Reduces Chemotherapy-Induced Early Menopause in Breast Cancer
L Del Mastro, L Boni, A Michelotti, T Gamucci, N Olmeo, S Gori, M Giordano, O Garrone, P Pronzato, C Bighin, A Levaggi, S Giraudi, N Cresti, E Magnolfi, T Scotto, C Vecchio, M Venturini
Yes
20110620
2011 Jul 20
JAMA
Effect of the Gonadotropin-Releasing Hormone Analogue Triptorelin on the Occurrence of Chemotherapy-Induced Early Menopause in P remenopausal Women With Breast Cancer
JAMA. 2011 Jul 20;306(3):269-276, L Del Mastro, L Boni, A Michelotti, T Gamucci, N Olmeo, S Gori, M Giordano, O Garrone, P Pronzato, C Bighin, A Levaggi, S Giraudi, N Cresti, E Magnolfi, T Scotto, C Vecchio, M Venturini
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Abstract
SUMMARY
OncologySTAT Editorial Team
In premenopausal women with breast cancer, chemotherapy may induce early menopause. Preclinical studies and phase II trials have demonstrated that ovarian suppression with a gonadotropin-releasing hormone (GnRH) analogue reduces ovarian toxicity and protects ovaries in 67% to 96% of women with breast cancer receiving chemotherapy. This multicenter, randomized, phase III study (PROMISE-GIM6) evaluated the efficacy of triptorelin, a GnRH analogue, in reducing the incidence of early menopause in young...
