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Donor Statin Treatment Protects Against Severe Acute Graft-Versus-Host Disease After Related Allogeneic Hematopoietic Cell Transplantation
Statins Protect Against Acute GVHD With Allogeneic Transplant
M Rotta, BE Storer, RF Storb, PJ Martin, S Heimfeld, A Peffer, DG Maloney, HJ Deeg, BM Sandmaier, FR Appelbaum, M Mielcarek
20091104
2009 Dec 4
Blood
Donor Statin Treatment Protects Against Severe Acute Graft-Versus-Host Disease After Related Allogeneic Hematopoietic Cell Transplantation
Blood. 2009 Dec 4;[Epub Ahead of Print], M Rotta, BE Storer, RF Storb, PJ Martin, S Heimfeld, A Peffer, DG Maloney, HJ Deeg, BM Sandmaier, FR Appelbaum, M Mielcarek
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Abstract
Abstract
We retrospectively analyzed outcomes among 567 patients with hematologic malignancies who had hematopoietic cell transplantation from HLA-identical sibling donors at a single institution between 2001 and 2007 for a correlation between statin use and risk of graft-versus-host disease (GVHD). Compared to allografts where neither the donor nor recipient was treated with a statin at the time of transplant (n=464), statin use by the donor and not the recipient (n=75) was associated with a decreased risk...
