Journal Scans
Dermatologic Infections in Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitor Therapy
Dermatologic Toxicity of Epidermal Growth Factor Receptor Inhibitors
R Eilers Jr, M Gandhi, J Patel, M Mulcahy, M Agulnik, T Hensing, M Lacouture
20091101
2009 Dec 1
J Natl Cancer Inst
Dermatologic Infections in Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitor Therapy
J Natl Cancer Inst. 2009 Dec 1;102(1):47-53, R Eilers Jr, M Gandhi, J Patel, M Mulcahy, M Agulnik, T Hensing, M Lacouture
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Abstract
SUMMARY
OncologySTAT Editorial Team
Various cellular processes are regulated by the epidermal growth factor receptor (EGFR), including cell differentiation, proliferation, and survival. EGFR dysregulation has been found in several malignancies, including lung, gastrointestinal, and head and neck cancers. This dysregulation appears to be associated with a poor response to treatment and a poor prognosis. Monoclonal antibodies directed against EGFR and small-molecule EGFR inhibitors have been developed and provide a rational approach...
