Journal Scans
Circulating Tumour Cells Early Predict Progression-Free and Overall Survival in Advanced Colorectal Cancer Patients Treated With Chemotherapy and Targeted Agents
Circulating Tumor Cells Predict Colon Cancer Outcome
J Tol, M Koopman, MC Miller, A Tibbe, A Cats, GJ Creemers, AH Vos, ID Nagtegaal, LW Terstappen, CJ Punt
Yes
20100401
2010 May 1
Ann Oncol
Circulating Tumour Cells Early Predict Progression-Free and Overall Survival in Advanced Colorectal Cancer Patients Treated With Chemotherapy and Targeted Agents
Ann Oncol. 2010 May 1;21(5):1006-1012, J Tol, M Koopman, MC Miller, A Tibbe, A Cats, GJ Creemers, AH Vos, ID Nagtegaal, LW Terstappen, CJ Punt
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Abstract
SUMMARY
OncologySTAT Editorial Team
In the treatment of advanced colorectal cancer (ACC), there is a growing need for early predictive markers of response to therapy, including therapy using targeted agents, to avoid unnecessary treatment in patients unlikely to respond. KRAS mutation status is one marker used to predict response to inhibitors of epidermal growth factor receptor, but markers with broader applicability would be useful. Tol et al evaluated the prognostic and predictive role of prediagnostic levels of circulating tumor...