Circulating Serum Free Light Chains as Predictive Markers of AIDS-Related Lymphoma

J Clin Oncol. 2010 Jan 4;[Epub Ahead of Print], O Landgren, JJ Goedert, CS Rabkin, WH Wilson, K Dunleavy, RA Kyle, JA Katzmann, SV Rajkumar, EA Engels

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Abstract

SUMMARY

OncologySTAT Editorial Team

Chronic human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin’s lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL), primary CNS lymphoma (PCNSL), and Burkitt lymphoma (BL). This risk may be related to loss of control of viruses such as Epstein Barr virus (EBV), which arises from immune dysregulation. Risk of lymphoma increases with the decline in the number of CD4 T-lymphocytes, but the risk is also related to B-cell dysfunction. Previous...

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