Chronic Myeloid Leukemia: A Prospective Comparison of Interphase Fluorescence in Situ Hybridization and Chromosome Banding Analysis for the Definition of Complete Cytogenetic Response, a Study of the GIMEMA CML WP
Blood. 2009 Oct 1; Epub ahead of print, N Testoni, G Marzocchi, S Luatti, M Amabile, C Baldazzi, M Stacchini, M Nanni, G Rege-Cambrin, E Giugliano, U Giussani, E Abruzzese, S Kerim, MG Grimoldi, A Gozzetti, B Crescenzi, C Carcassi, P Bernasconi, A Cuneo, F Albano, G Fugazza, A Zaccaria, G Martinelli, F Pane, G Rosti, M Baccarani
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Abstract
Abstract
In chronic myeloid leukemia (CML) different complementary methods are available to monitor the response to therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization (I-FISH) and Real Time Quantitative Polymerase Chain Reaction (RT-Q-PCR). The GIMEMA (Gruppo Italiano Malattie Ematologiche Adulto) CML Working Party (WP) has performed a prospective study to compare CBA and I-FISH for the definition of Complete Cytogenetic Response (CCgR). 665 samples were evaluated by...
SUMMARY
OncologySTAT Editorial Team
This is the first report showing that the presence of IFE oligoclonal bands in patients with MM in CR frequently results in an abnormal serum FLC ratio. Our results question the current definition of sCR and support that its possible prognostic relevance should be studied taking into account the presence of ASIPs in a multivariate analysis.
