Journal Scans
Breast Cancer After Use of Estrogen Plus Progestin in Postmenopausal Women
Breast Cancer Risk Declines After Discontinuation of HRT
RT Chlebowski, LH Kuller, RL Prentice, ML Stefanick, JE Manson, M Gass, AK Aragaki, JK Ockene, DS Lane, GE Sarto, A Rajkovic, R Schenken, SL Hendrix, PM Ravdin, TE Rohan, S Yasmeen, G Anderson, for the WHI Investigators
20090105
2009 Feb 5
N Engl J Med
Breast Cancer After Use of Estrogen Plus Progestin in Postmenopausal Women
N Engl J Med. 2009 Feb 5;360(6):573-587, RT Chlebowski, LH Kuller, RL Prentice, ML Stefanick, JE Manson, M Gass, AK Aragaki, JK Ockene, DS Lane, GE Sarto, A Rajkovic, R Schenken, SL Hendrix, PM Ravdin, TE Rohan, S Yasmeen, G Anderson, for the WHI Investigators
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Abstract
SUMMARY
OncologySTAT Editorial Team
The Women’s Health Initiative (WHI) study was halted when a 2002 analysis indicated that the risks of hormone replacement therapy (HRT) for postmenopausal women outweighed the benefits. In addition to having increased breast cancer risk, women treated with daily HRT had larger and more aggressive tumors, more frequent abnormal mammogram results, and more breast biopsies than their placebo-treated counterparts. From 2002 forward, use of HRT by postmenopausal women in the United States was drastically...
