Association of ACE Inhibitors and Angiotensin Receptor Blockers With Keratinocyte Cancer Prevention in the Randomized VATTC Trial
J Natl Cancer Inst. 2008 Sept 3;100(17):1223-1232, JB Christian, KL Lapane, AL Hume, CB Eaton, MA Weinstock, for the VATTC Trial
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Abstract
Abstract
BACKGROUND: The observation that angiotensin II is a potent angiogenic and growth factor raises the possibility that blocking its effects could reduce the incidence of cancer. We evaluated associations between use of angiotensin-converting enzyme (ACE) inhibitors and of angiotensin receptor blockers (ARBs) and keratinocyte cancer incidence in a population at high risk of the disease. METHODS: A cohort study design was conducted using data on 1051 participants in the randomized Department of Veterans...
SUMMARY
OncologySTAT Editorial Team
Sunscreen use and sun avoidance have limited effectiveness as strategies to prevent keratinocyte cancers, such as squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs). Previous basic research and epidemiologic studies have suggested that angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) may have chemopreventive activity against cancer. A cohort study, sponsored by the Department of Veterans Affairs and the American Cancer Society, was performed to...
