Aspirin and Non-Steroidal Anti-inflammatory Drugs for Cancer Prevention: An International Consensus Statement

Lancet Oncol. 2009 May 1;10(5):501-507, J Cuzick, F Otto, JA Baron, PH Brown, J Burn, P Greenwald, J Jankowski, C La Vecchia, F Meyskens, HJ Senn, M Thun

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Abstract

Abstract

Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and probably other cancer types; however, data on the risk–benefit profile for cancer prevention are insufficient and no definitive recommendations can be made. Aspirin has emerged as the most likely NSAID for use in chemoprevention because of its known cardiovascular benefit and available safety and efficacy data. Other traditional NSAIDs, particularly sulindac,...

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