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Analysis of Factors Influencing Outcome in Patients With In-Transit Malignant Melanoma Undergoing Isolated Limb Perfusion Using Modern Treatment Parameters
Safety and Efficacy of Isolated Limb Perfusion for In-Transit Malignant Melanoma
HR Alexander Jr, DL Fraker, DL Bartlett, SK Libutti, SM Steinberg, P Soriano, T Beresnev
20091009
2009 Nov 9
J Clin Oncol
Analysis of Factors Influencing Outcome in Patients With In-Transit Malignant Melanoma Undergoing Isolated Limb Perfusion Using Modern Treatment Parameters
J Clin Oncol. 2009 Nov 9; Epub ahead of print, HR Alexander Jr, DL Fraker, DL Bartlett, SK Libutti, SM Steinberg, P Soriano, T Beresnev
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Abstract
SUMMARY
OncologySTAT Editorial Team
A significant proportion of patients with melanoma will develop regionally advanced disease of the extremity. Isolated limb perfusion (ILP) is a surgical procedure that delivers systemic therapy intravascularly to the affected region. ILP has the advantage of delivering higher regional drug concentrations while limiting the toxicity from systemic administration. However, although ILP has been used for treatment of in-transit extremity melanoma for several decades, it is has not gained widespread...
