Journal Scans
Allogeneic Virus-Specific T Cells With HLA Alloreactivity Do Not Produce GVHD in Human Subjects
GVHD Not Induced by HLA Alloreactive Virus-Specific CTLs
JJ Melenhorst, AM Leen, CM Bollard, MF Quigley, DA Price, CM Rooney, MK Brenner, AJ Barrett, HE Heslop
20100713
2010 Aug 13
Blood
Allogeneic Virus-Specific T Cells With HLA Alloreactivity Do Not Produce GVHD in Human Subjects
Blood. 2010 Aug 13;[Epub Ahead of Print], JJ Melenhorst, AM Leen, CM Bollard, MF Quigley, DA Price, CM Rooney, MK Brenner, AJ Barrett, HE Heslop
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Abstract
Abstract
Adoptive transfer of viral antigen-specific memory T cells can reconstitute antiviral immunity but in a recent report by Amir et al, a majority of virus-specific CTL lines showed in vitro cross-reactivity against allo-HLA molecules as measured by gamma interferon secretion. We therefore reviewed our clinical experience with adoptive transfer of allogeneic hematopoietic stem cell transplant donor-derived virus-specific CTLs in 153 recipients including 73 instances where there was HLA-mismatch. There...
