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Allogeneic Stem Cell Transplantation After Reduced-Intensity Conditioning in Patients With Myelofibrosis: A Prospective, Multicenter Study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Reduced-Intensity Conditioning With Allo-SCT in Patients With Myelofibrosis
N Kroger, E Holler, G Kobbe, M Bornhaeuser, R Schwerdtfeger, H Baurmann, A Nagler, W Bethge, M Stelljes, L Uharek, H Wandt, A Burchert, P Corradini, J Schubert, M Kaufmann, P Dreger, GG Wulf, H Einsele, T Zabelina, HM Kvasnicka, J Thiele, R Brand, AR Zander, D Niederwieser, TM de Witte
20090907
2009 Oct 7
Blood
Allogeneic Stem Cell Transplantation After Reduced-Intensity Conditioning in Patients With Myelofibrosis: A Prospective, Multicenter Study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Blood. 2009 Oct 7; Epub ahead of print, N Kroger, E Holler, G Kobbe, M Bornhaeuser, R Schwerdtfeger, H Baurmann, A Nagler, W Bethge, M Stelljes, L Uharek, H Wandt, A Burchert, P Corradini, J Schubert, M Kaufmann, P Dreger, GG Wulf, H Einsele, T Zabelina, HM Kvasnicka, J Thiele, R Brand, AR Zander, D Niederwieser, TM de Witte
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Abstract
Abstract
From 2002 to 2007, 103 patients with primary myelofibrosis or post ET/PV myelofibrosis and a median age of 55 years (range, 32-68) were included in a prospective multicenter phase II trial to determine efficacy of a busulfan (10 mg/kg) /fludarabine (180mg/m2)-based reduced-intensity conditioning regimen (RIC) followed by allogeneic stem cell transplantation from related (n=33) or unrelated donors (n=70). All but two patients (2%) showed leukocyte and platelet engraftment after a median of 18 and...
