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Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents With Recurrent and Refractory Hodgkin's Lymphoma: An Analysis of the European Group for Blood and Marrow Transplantation
ASCT in Children and Adolescents With Recurrent, Refractory Hodgkin's Lymphoma
A Claviez, C Canals, D Dierickx, J Stein, I Badell, A Pession, S Mackinnon, S Slavin, J-H Dalle, MJ Chacon, M Sarhan, RF Wynn, M Suttorp, G Dini, A Sureda, N Schmitz
20090504
2009 Jun 4
Blood
Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents With Recurrent and Refractory Hodgkin's Lymphoma: An Analysis of the European Group for Blood and Marrow Transplantation
Blood. 2009 Jun 4;Epub ahead of print, A Claviez, C Canals, D Dierickx, J Stein, I Badell, A Pession, S Mackinnon, S Slavin, J-H Dalle, MJ Chacon, M Sarhan, RF Wynn, M Suttorp, G Dini, A Sureda, N Schmitz
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Abstract
Abstract
Ninety-one children and adolescents 18 years who received allogeneic hematopoietic stem cell transplantation (HSCT) for relapsed or refractory Hodgkin's lymphoma (HL) were analyzed. Fifty-one patients received reduced intensity conditioning (RIC), 40 patients received myeloablative conditioning (MAC). Non-relapse mortality (NRM) at 1 year was 21±4%, with comparable results after RIC or MAC. Probabilities of relapse at 2 and 5 years were 36±5% and 44±6%, respectively. RIC was associated with an increased...
