Allogeneic Hematopoietic Cell Transplantation for Hematological Malignancy: Relative Risks and Benefits of Double Umbilical Cord Blood

Blood. 2010 Aug 4;[Epub Ahead of Print], CG Brunstein, JA Gutman, DJ Weisdorf, AE Woolfrey, TE Defor, TA Gooley, MR Verneris, FR Appelbaum, JE Wagner, C Delaney

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Abstract

Abstract

Effectiveness of double umbilical cord blood (dUCB) grafts relative to conventional marrow and mobilized peripheral blood from related and unrelated donors has yet to be established. We studied 536 patients at the Fred Hutchinson Cancer Research Center and University of Minnesota with malignant disease who underwent transplant with an HLA matched related donor (MRD, n=204), HLA allele matched or 1-antigen mismatched unrelated adult donor (MUD, n=152; MMUD, n=52) or 4-6/6 HLA matched dUCB (n=128)...

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