Abnormal Serum Free Light Chain Ratio in Patients With Multiple Myeloma in Complete Remission Has Strong Association With the Presence of Oligoclonal Bands: Implications for Stringent Complete Remission Definition
Blood. 2009 Oct 1;114(14):3024-3032, C Fernandez de Larrea , MTeresa Cibeira, M Elena, JI Arostegui, M Rovira, X Filella, J Yague, J Blade
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Abstract
Abstract
The prevalence of an abnormal serum free light chain (FLC) ratio in 34 patients with multiple myeloma (MM) in complete response (CR) after hematopoietic stem cell transplantation was studied. Fourteen of 34 patients (41.2%) had an abnormal FLC ratio. The frequency of abnormal FLC ratio in patients with or without oligoclonal bands was 72.7% vs. 26%, respectively (p=0.023). The median value of FLC ratio was 2.55 (CI 95%, 1.89 - 3.20) in patients with oligoclonal bands vs. 0.87 (CI 95%, 0.70 - 1.04)...
SUMMARY
OncologySTAT Editorial Team
This is the first report showing that the presence of IFE oligoclonal bands in patients with MM in CR frequently results in an abnormal serum FLC ratio. Our results question the current definition of sCR and support that its possible prognostic relevance should be studied taking into account the presence of ASIPs in a multivariate analysis.
