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A Phase 3 Randomized, Placebo-Controlled, Double-Blind, Clinical Trial of the Effect of Modafinil on Cancer-Related Fatigue Among 631 Patients Receiving Chemotherapy
Modafinil Effective for Chemotherapy-Related Fatigue
P Jean-Pierre, GR Morrow, JA Roscoe, C Heckler, S Mohile, M Janelsins, L Peppone, A Hemstad, BT Esparaz, JO Hopkins
20100615
2010 Jul 15
Cancer
A Phase 3 Randomized, Placebo-Controlled, Double-Blind, Clinical Trial of the Effect of Modafinil on Cancer-Related Fatigue Among 631 Patients Receiving Chemotherapy
Cancer. 2010 Jul 15;116(14):3513-3520, P Jean-Pierre, GR Morrow, JA Roscoe, C Heckler, S Mohile, M Janelsins, L Peppone, A Hemstad, BT Esparaz, JO Hopkins
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Abstract
SUMMARY
OncologySTAT Editorial Team
Most patients with cancer and those undergoing chemotherapy experience persistent symptoms of fatigue despite pharmacologic and psychosocial interventions. Clearly, a more effective management approach to this common symptom is warranted. Toward this end, researchers investigated the role of modafinil, a nonamphetamine-based stimulant, in the management of fatigue, evaluating specifically patients’ treatment adherence, psychosocial functioning, and quality of life (QOL). This was a randomized, double-blind,...
