Journal Scans
AML With Mutated NPM1 Carrying a Normal or Aberrant Karyotype Show Overlapping Biologic, Pathologic, Immunophenotypic, and Prognostic Features
NPM1 Mutation Is a Defining Molecular Feature in AML
C Haferlach, C Mecucci, S Schnittger, A Kohlmann, M Mancini, A Cuneo, N Testoni, G Rege-Cambrin, A Santucci, M Vignetti, P Fazi, MP Martelli, T Haferlach, B Falini
20090901
2009 Oct 1
Blood
AML With Mutated NPM1 Carrying a Normal or Aberrant Karyotype Show Overlapping Biologic, Pathologic, Immunophenotypic, and Prognostic Features
Blood. 2009 Oct 1;114(14):3024-3032, C Haferlach, C Mecucci, S Schnittger, A Kohlmann, M Mancini, A Cuneo, N Testoni, G Rege-Cambrin, A Santucci, M Vignetti, P Fazi, MP Martelli, T Haferlach, B Falini
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Abstract
Abstract
Acute myeloid leukemia (AML) with mutated NPM1 usually carries normal karyotype (NK), but it may harbor chromosomal aberrations whose significance remains unclear. We addressed this question in 631 AML patients with mutated/cytoplasmic NPM1. An abnormal karyotype (AK) was present in 93 of 631 cases (14.7%), the most frequent abnormalities being +8, +4, –Y, del(9q), +21. Chromosome aberrations in NPM1-mutated AML were similar to, but occurred less frequently than additional chromosome changes found...
