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AML1/RUNX1 Mutations in 470 Adult Patients With de Novo Acute Myeloid Leukemia: Prognostic Implication and Interaction With Other Gene Alterations
AML1/RUNX1 Mutations Are Prognostic in AML
J-L Tang, H-A Hou, C-Y Chen, C-Y Liu, W-C Chou, M-H Tseng, C-F Huang, F-Y Lee, M-C Liu, M Yao, S-Y Huang, B-S Ko, S-C Hsu, S-J Wu, W Tsay, Y-C Chen, L-I Lin, H-F Tien
20090906
2009 Oct 6
Blood
AML1/RUNX1 Mutations in 470 Adult Patients With de Novo Acute Myeloid Leukemia: Prognostic Implication and Interaction With Other Gene Alterations
Blood. 2009 Oct 6; Epub ahead of print, J-L Tang, H-A Hou, C-Y Chen, C-Y Liu, W-C Chou, M-H Tseng, C-F Huang, F-Y Lee, M-C Liu, M Yao, S-Y Huang, B-S Ko, S-C Hsu, S-J Wu, W Tsay, Y-C Chen, L-I Lin, H-F Tien
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Abstract
Abstract
Somatic mutation of AML1/RUNX1(RUNX1) gene is seen in acute myeloid leukemia (AML) M0 subtype and AML transformed from myelodysplastic syndrome, but the impact of this gene mutation on survival in AML patients remains unclear. In this study, we sought to determine the clinical implications of RUNX1 mutations in 470 adult patients with de novo non-M3 AML. Sixty-three distinct RUNX1 mutations were identified in 62 individuals (13.2%); 32 were in N-terminal and 31, C-terminal. The RUNX1 mutation was...
