Ocular melanoma metastatic to the pancreas after a 28-year disease-free interval

Surgery. 2010 Jul;148(1):151-154, Parsia A. Vagefi, Lars Stangenberg, Gregor Krings, David G. Forcione, Jennifer A. Wargo

DiscussionMalignant melanoma has an incidence of roughly 20 in 100,000 and primarily involves the skin. Five percent of the lesions, however, are found in the eye,1 and melanoma accounts for the most common malignancy arising in the eye. In contrast with cutaneous melanoma, the ocular variant rarely metastasizes to lymph nodes owing to the lack of lymphatic vessels in the uveal tract, and most commonly metastasizes to the liver.1 Although pancreatic metastases occur in fewer than 2% of patients with...

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