Initial Animal Studies for NOTESThe growing capabilities of therapeutic flexible endoscopy have ushered in a new era in the treatment of gastrointestinal conditions.6 The natural orifices may provide the entry point for surgical interventions in the peritoneal cavity, thereby avoiding abdominal wall incisions.6 NOTES certainly has the potential to achieve this and with careful nurturing may come to fruition as a true paradigm shift much in the same way as laparoscopic surgery did 20 years ago.The...