p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy
Takahiro Hasebe, Nobuko Tamura, Nao Okada, Takashi Hojo, Sadako Akashi-Tanaka, Chikako Shimizu, Histoshi Tsuda, Tatsuhiro Shibata, Yuko Sasajima, Motoki Iwasaki, Takayuki Kinoshita
20100101
2010 Feb 1
Hum Pathol
p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy
Hum Pathol. 2010 Feb;41(2):262-270, Takahiro Hasebe, Nobuko Tamura, Nao Okada, Takashi Hojo, Sadako Akashi-Tanaka, Chikako Shimizu, Histoshi Tsuda, Tatsuhiro Shibata, Yuko Sasajima, Motoki Iwasaki, Takayuki Kinoshita
ABSTRACT
The purpose of this study was to determine whether p53 immunoreactivity in tumor-stromal fibroblasts assessed by the Allred scoring system in biopsy specimens obtained before neoadjuvant therapy and assessed in surgical specimens obtained after neoadjuvant therapy is significantly associated with nodal metastasis by invasive ductal carcinoma and with the outcome of 318 patients with invasive ductal carcinoma who received neoadjuvant therapy, according to UICC pathologic TNM stage, in multivariate...
