Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer
Parham Minoo, Kristi Baker, Daniel Baumhoer, Luigi Terracciano, Alessandro Lugli, Inti Zlobec
20100001
2010 Jan 1
Hum Pathol
Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer
Hum Pathol. 2010 Jan;41(1):70-78, Parham Minoo, Kristi Baker, Daniel Baumhoer, Luigi Terracciano, Alessandro Lugli, Inti Zlobec
The aim of this study was to determine the prognostic significance of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in colorectal cancer stratified by mismatch repair status and to determine their contribution to the aggressive phenotype predicted by loss of E-cadherin and apoptosis protease activating factor-1 (APAF-1). Immunohistochemistry for uPA and uPAR was performed on a tissue microarray comprising 811 mismatch repair-proficient and 164 mismatch repair-deficient colorectal...
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