Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon
Sakiko Hiraoka, Jun Kato, Joichiro Horii, Shunsuke Saito, Keita Harada, Hideyuki Fujita, Motoaki Kuriyama, Koji Takemoto, Toshio Uraoka, Kazuhide Yamamoto
20100001
2010 Jan 1
Hum Pathol
Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon
Hum Pathol. 2010 Jan;41(1):38-47, Sakiko Hiraoka, Jun Kato, Joichiro Horii, Shunsuke Saito, Keita Harada, Hideyuki Fujita, Motoaki Kuriyama, Koji Takemoto, Toshio Uraoka, Kazuhide Yamamoto
ABSTRACT
The aim of this study is to evaluate the methylation status of normal colonic mucosa in relation to the stage of neoplasia arising from the mucosa. The methylation status of 2 age-related loci (ESR1 and MYOD1) and global methylation (the mean of Alu and Sat2) in the normal colonic mucosa of 156 patients with and without colorectal neoplasia were examined. The distal colon and proximal colon were analyzed separately because neoplasia is biologically and clinically different between these sites. The...
