Invasive ductal breast cancer within a malignant phyllodes tumor: case report and assessment of clonality
Stephan Macher-Goeppinger, Frederik Marme, Benjamin Goeppert, Roland Penzel, Peter Schirmacher, Hans Peter Sinn, Sebastian Aulmann
20100101
2010 Feb 1
Hum Pathol
Invasive ductal breast cancer within a malignant phyllodes tumor: case report and assessment of clonality
Hum Pathol. 2010 Feb;41(2):293-296, Stephan Macher-Goeppinger, Frederik Marme, Benjamin Goeppert, Roland Penzel, Peter Schirmacher, Hans Peter Sinn, Sebastian Aulmann
ABSTRACT
Invasive carcinomas arising within fibroepithelial tumors represent an uncommon manifestation of breast cancer. We report the case of a 70-year-old woman who underwent mastectomy for a malignant phyllodes tumor measuring 6 cm. Histological workup of the specimen revealed a high-grade invasive ductal carcinoma 2.5 cm in diameter within the phyllodes tumor. DNA was isolated from microdissected epithelial and stromal components of the phyllodes tumor as well as from the invasive ductal carcinoma cells....
