We very much appreciate the comments by Bilous et al further expanding the important discussion on HER2 amplification and overexpression in gastric cancer. The data provided by Bilous et al are to a large extent consistant with our findings. For example, their unpublished tissue multi array (TMA) study of 170 gastric cancer cases showed strikingly similar results: In 19.4% (n = 33) of the cases gene amplification strongly correlated with protein overexpression (as compared to 16% in our series of...