HER-2 amplification is highly homogenous in gastric cancer20100208104407
Michael Bilous, Robert Y. Osamura, J. Rüschoff, Marc van de Vijver, Wedad Hanna, Frederique Penault-Llorca, Patrick Roche
20100101
2010 Feb 1
Hum Pathol
HER-2 amplification is highly homogenous in gastric cancer
Hum Pathol. 2010 Feb;41(2):304-305, Michael Bilous, Robert Y. Osamura, J. Rüschoff, Marc van de Vijver, Wedad Hanna, Frederique Penault-Llorca, Patrick Roche
We have read the article of Marx et al [1] with great interest because it focuses on HER2 expression in gastric cancer, a tumor that is very likely to become one of the next indications for HER2-targeted therapy using trastuzumab [2].We performed a similar study using TMAs from 170 gastric cancer cases using CONFIRM anti-HER2/neu (4B5) to assess protein overexpression and INFORM HER2 DNA assay for gene amplification. In 19.4% of cases (n = 33), gene amplification strongly correlated with protein...
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