Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer

Hum Pathol. 2010 Jan;41(1):48-58, De-Yuan Fu, Zhi-Min Wang, Bei-Lan Wang, Li Chen, Wen-Tao Yang, Zhen-Zhou Shen, Wei Huang, Zhi-Ming Shao

ABSTRACT

EphA5 is a member of the Eph receptor tyrosine kinase family, which plays a critical role in the regulation of carcinogenesis. Our previous DNA methylation microarray results suggested that the CpG islands in the EphA5 promoter exhibited higher methylation levels in breast cancer tissues. In this study, we further analyzed EphA5 gene expression profiles, methylation status, and clinical implications in breast cancer. We found that the level of EphA5 mRNA was dramatically decreased in 5 different...

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