Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer
De-Yuan Fu, Zhi-Min Wang, Bei-Lan Wang, Li Chen, Wen-Tao Yang, Zhen-Zhou Shen, Wei Huang, Zhi-Ming Shao
20100001
2010 Jan 1
Hum Pathol
Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer
Hum Pathol. 2010 Jan;41(1):48-58, De-Yuan Fu, Zhi-Min Wang, Bei-Lan Wang, Li Chen, Wen-Tao Yang, Zhen-Zhou Shen, Wei Huang, Zhi-Ming Shao
ABSTRACT
EphA5 is a member of the Eph receptor tyrosine kinase family, which plays a critical role in the regulation of carcinogenesis. Our previous DNA methylation microarray results suggested that the CpG islands in the EphA5 promoter exhibited higher methylation levels in breast cancer tissues. In this study, we further analyzed EphA5 gene expression profiles, methylation status, and clinical implications in breast cancer. We found that the level of EphA5 mRNA was dramatically decreased in 5 different...
