DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors
Md. Mustafizur Rahman, Zhi Rong Qian, Elaine Lu Wang, Katsuhiko Yoshimoto, Masahiko Nakasono, Razia Sultana, Tomoyuki Yoshida, Toshitetsu Hayashi, Reiji Haba, Mitsuaki Ishida, Hidetoshi Okabe, Toshiaki Sano
20100701
2010 Aug 1
Hum Pathol
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors
Hum Pathol. 2010 Aug;41(8):1069-1078, Md. Mustafizur Rahman, Zhi Rong Qian, Elaine Lu Wang, Katsuhiko Yoshimoto, Masahiko Nakasono, Razia Sultana, Tomoyuki Yoshida, Toshitetsu Hayashi, Reiji Haba, Mitsuaki Ishida, Hidetoshi Okabe, Toshiaki Sano
The alteration of DNA methylation is one of the most common epigenetic changes in human cancers. Three genes, namely, DNA methyltransferase 1, 3a, and 3b, which code for DNA methyltransferases that affect promoter methylation status, are thought to play an important role in the development of cancers and may be good anticancer therapy targets. The methylation of tumor suppressor genes has been reported in gastroenteropancreatic neuroendocrine tumors; however, there have been no studies about DNA...
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