I read with interest the article by Takubo et al [1]. This collaborative work between Japanese and German workers reported that more than 70% of their cases showed cardiac/fundic-type mucosa adjacent to the tumors studied and proposed it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells.While one commends the efforts of the authors, however, a few pertinent questions need answering to further understand the importance...