CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas
Robert F. Luo, Shuchun Zhao, Robert Tibshirani, June H. Myklebust, Mrinmoy Sanyal, Rosemary Fernandez, Dita Gratzinger, Robert J. Marinelli, Zhi Shun Lu, Anna Wong, Ronald Levy, Shoshana Levy, Yasodha Natkunam
20100101
2010 Feb 1
Hum Pathol
CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas
Hum Pathol. 2010 Feb;41(2):271-280, Robert F. Luo, Shuchun Zhao, Robert Tibshirani, June H. Myklebust, Mrinmoy Sanyal, Rosemary Fernandez, Dita Gratzinger, Robert J. Marinelli, Zhi Shun Lu, Anna Wong, Ronald Levy, Shoshana Levy, Yasodha Natkunam
CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells. Immunohistologic analysis in normal hematopoietic tissue showed strong staining for CD81 in normal germinal center B cells, a cell type in which its increased expression has not been previously recognized. High-dimensional flow cytometry analysis of normal hematopoietic tissue confirmed that among B- and T-cell subsets, germinal center B cells showed the...
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