Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma
Naoki Ogane, Masanori Yasuda, Michio Shimizu, Masaki Miyazawa, Shingo Kamoshida, Akiko Ueda, Ken Takata, Yuji Sakuma, Yohei Miyagi, Yoichi Kameda
20100101
2010 Feb 1
Ann Diagn Pathol
Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma
Ann Diagn Pathol. 2010 Feb;14(1):23-29, Naoki Ogane, Masanori Yasuda, Michio Shimizu, Masaki Miyazawa, Shingo Kamoshida, Akiko Ueda, Ken Takata, Yuji Sakuma, Yohei Miyagi, Yoichi Kameda
This study was conducted to clarify whether or not expressions of hypoxia-related molecules would have clinicopathological significance in squamous cell carcinoma (SCC) of the esophagus. Expressions of hypoxia inducible factor-1 alpha (HIF-1α), glucose transporter 1 (GLUT-1) and RAC-1 were immunohistochemically analyzed in 96 surgically resected SCCs at pT1b (sm1, 12 cases; sm2, 35 cases; sm3, 49 cases). They were divided into a lymph node metastasis (LNM)–positive group composed of 44 cases and...
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