Physicians and patients continue to struggle with the often-quoted conundrum of Willett F. Whitmore Jr: Is cure of prostate cancer possible when necessary and necessary when possible?The European Randomized Study of Prostate Cancer Screening (ERSPC)1 has provided unequivocal evidence that cure is possible when necessary, by showing a 20% reduction in prostate cancer mortality among screened men (31% reduction after adjusting for noncompliance in the screening arm and for screening in the control...