Expression of annexin A1 mRNA in peripheral blood from oral squamous cell carcinoma patients
Paula Cristina Batista Faria, Angela Aparecida Servino Sena, Rafael Nascimento, Washington João Carvalho, Adriano Mota Loyola, Sindeval José Silva, Antônio Francisco Durighetto, Anísio Domingos Oliveira, Sonia Maria Oliani, Luiz Ricardo Goulart
20100001
2010 Jan 1
Oral Oncol
Expression of annexin A1 mRNA in peripheral blood from oral squamous cell carcinoma patients
Oral Oncol. 2010 Jan;46(1):25-30, Paula Cristina Batista Faria, Angela Aparecida Servino Sena, Rafael Nascimento, Washington João Carvalho, Adriano Mota Loyola, Sindeval José Silva, Antônio Francisco Durighetto, Anísio Domingos Oliveira, Sonia Maria Oliani, Luiz Ricardo Goulart
Several studies have been suggesting annexin A1 protein as an active player in tumorigenesis of many organs. Nevertheless, its tumor biomarker role has been mainly studied in tissues by immunohistochemistry or cell culture. Hence, in this investigation, the peripheral blood from 27 oral squamous cell carcinoma (OSCC) patients and 25 negative control individuals were examined by quantitative real-time PCR. Down-regulated ANXA1 expression at mRNA level was observed in OSCC samples (p=0.026). Significantly...
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