Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma
Damien Ythier, Elisabeth Brambilla, Romuald Binet, Damien Nissou, Aurélien Vesin, Florence de Fraipont, Denis Moro-Sibilot, Sylvie Lantuejoul, Christian Brambilla, Sylvie Gazzeri, Rémy Pedeux
20100701
2010 Aug 1
Lung Cancer
Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma
Lung Cancer. 2010 Aug;69(2):180-186, Damien Ythier, Elisabeth Brambilla, Romuald Binet, Damien Nissou, Aurélien Vesin, Florence de Fraipont, Denis Moro-Sibilot, Sylvie Lantuejoul, Christian Brambilla, Sylvie Gazzeri, Rémy Pedeux
ING2 is a candidate tumor suppressor gene involved in cell cycle control, apoptosis and senescence. Furthermore, we have recently shown that loss of ING2 expression is associated with increased genome instability. We investigated its status in a series of 120 non-small cell lung cancer (NSCLC) by using immunohistochemistry (IHC). The results showed that ING2 protein expression is downregulated in more than 50% of NSCLC, with a higher frequency in adenocarcinoma (ADK) as compared to squamous cell...
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