DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
Stephen E. Hawes, Joshua E. Stern, Qinghua Feng, Linda W. Wiens, Janet S. Rasey, Hiep Lu, Nancy B. Kiviat, Hubert Vesselle
20100701
2010 Aug 1
Lung Cancer
DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
Lung Cancer. 2010 Aug;69(2):172-179, Stephen E. Hawes, Joshua E. Stern, Qinghua Feng, Linda W. Wiens, Janet S. Rasey, Hiep Lu, Nancy B. Kiviat, Hubert Vesselle
BackgroundWe previously identified a number of genes which were methylated significantly more frequently in the tumor compared to the non-cancerous lung tissues from non-small cell lung cancer (NSCLC) patients. Detection of methylation profiles of genes in NSCLC could provide insight into differential pathways to malignancy and lead to strategies for better treatment of individuals with NSCLC.MethodsWe determined the DNA methylation status of 27 genes using quantitative MethyLight assays in lung...
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