Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
Ying Xie, Nevins W. Todd, Zhenqiu Liu, Min Zhan, HongBin Fang, Hong Peng, Mohammed Alattar, Janaki Deepak, Sanford A. Stass, Feng Jiang
20100101
2010 Feb 1
Lung Cancer
Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
Lung Cancer. 2010 Feb;67(2):170-176, Ying Xie, Nevins W. Todd, Zhenqiu Liu, Min Zhan, HongBin Fang, Hong Peng, Mohammed Alattar, Janaki Deepak, Sanford A. Stass, Feng Jiang
Analysis of molecular genetic markers in biological fluids has been proposed as a useful tool for cancer diagnosis. MicroRNAs (miRNAs) are small regulatory RNAs that are frequently dysregulated in lung cancer and have shown promise as tissue-based markers for its prognostication. The aim of this study was to determine whether aberrant miRNA expression can be used as a marker in sputum specimen for the diagnosis of non-small cell lung cancer (NSCLC). Experimental design: expressions of mature miRNAs,...
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