Sustained cytokinemia and chemokinemia concomitant with juvenile myelomonocytic leukemia in an infant with Noonan syndrome
Kaoru Okazaki, Jun Unemoto, Masatoshi Kondo, Takashi Kusaka, Kunihisa Kozawa, Masakazu Yoshizumi, Akira Shimada, Junko Takita, Takashi Kaneko, Takehiro Hama, Hirokazu Kimura
20100801
2010 Sept 1
Leuk Res
Sustained cytokinemia and chemokinemia concomitant with juvenile myelomonocytic leukemia in an infant with Noonan syndrome
Leuk Res. 2010 Sept;34(9), Kaoru Okazaki, Jun Unemoto, Masatoshi Kondo, Takashi Kusaka, Kunihisa Kozawa, Masakazu Yoshizumi, Akira Shimada, Junko Takita, Takashi Kaneko, Takehiro Hama, Hirokazu Kimura
1IntroductionNoonan syndrome (NS) is a multiple congenital abnormality syndrome with a prevalence of around 1 in 15,000 [1]. NS can be complicated by various hematologic derangements, including juvenile myelomonocytic leukemia (JMML) [1,2]. JMML itself is responsible for approximately 2% of juvenile leukemia cases and the outcome is extremely poor. Although most cases of JMML with NS show spontaneous remission, a small number of cases can be refractory and lethal, and their mechanisms are as yet...
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