Safe treatment of a patient with CML using dasatinib after prior retinal oedema due to imatinib

Leuk Res. 2008 Nov;32(11):1789-1790, Ashish Bajel, Saf Bassili, John F. Seymour

1IntroductionImatinib, a Bcr-Abl kinase inhibitor is the standard therapy for all phases of CML [1]. Imatinib also inhibits other kinases, including ABL, c-kit, PDGFR-α and -β, ARG and c-fms. While the activity against these targets is being exploited therapeutically, it may also underlie some of the adverse effects reported. The most common adverse effects include superficial oedema, nausea, muscle cramps, musculoskeletal pain, rash, fatigue, diarrhoea and myelosuppression [2]. Ocular toxicities...

NOT A MEMBER?

Registration is FREE

  • Up-to-date oncology news
  • Journal article summaries
  • Commentaries and interviews
  • Drug and interactions database
  • Chemotherapy regimens
  • Daily e-newsletters

 

Editors' Choice

Long-Term Posttransplant Bortezomib Boosts Outcome in Myeloma With del(17p13)

Sign up for our newsletters

Too busy to follow cancer's top stories? Sign-up for 1 or more of our free newsletters -- delivered weekly to your inbox.

Cancer Type

  • Bladder
  • Bone
  • Breast
  • Breast (ER-Positive)
  • CNS/Brain
  • Colon and Rectum
  • Endocrine System
  • Esophagus
  • GYN (Non-Ovary)
  • GYN (Ovary)
  • Head and Neck
  • Hodgkin's Lymphoma
  • Kidney (Renal Cell)
  • Leukemia
  • Liver and Bile Duct
  • Lung
  • Multiple Myeloma
  • Myelodysplastic Syndrome
  • Myeloproliferative Diseases
  • Non-Hodgkin's Lymphoma
  • Pancreas
  • Pediatric Cancers
  • Prostate
  • Rare Cancers
  • Skin
  • Soft-Tissue Sarcoma
  • Stomach
  • Testicle
  • Forgot your password?
    Not a member? Free registration