Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation
T. Kaddar, W.W. Chien, Y. Bertrand, M.P. Pages, J.P. Rouault, G. Salles, M. Ffrench, J.P. Magaud
20090801
2009 Sept 1
Leuk Res
Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation
Leuk Res. 2009 Sept;33(9):1217-1223, T. Kaddar, W.W. Chien, Y. Bertrand, M.P. Pages, J.P. Rouault, G. Salles, M. Ffrench, J.P. Magaud
miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleukocytosis and poor cytogenetic groups. In the whole group and in B-cell ALLs, disease-free survival (DFS) was significantly shorter for miR-16 above quartile 75. In T-cell ALLs, for both...
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