Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines
Felipe Bedoya, Maria M. Medveczky, Troy C. Lund, Andras Perl, Joseph Horvath, Stephen D. Jett, Peter G. Medveczky
20091001
2009 Nov 1
Leuk Res
Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines
Leuk Res. 2009 Nov;33(11):1499-1504, Felipe Bedoya, Maria M. Medveczky, Troy C. Lund, Andras Perl, Joseph Horvath, Stephen D. Jett, Peter G. Medveczky
Since most oncogenic viruses persist as extrachromosomal covalently closed circular DNA (cccDNA) in tumor cells, we developed an assay to visualize and identify cccDNA in primary lymphomas. We identified concatemers of the mitochondrial genome in all samples analyzed, but not in normal lymphocytes. One AIDS-associated lymphoma (EL) was further studied in detail as its mitochondrial genome consisted of tandem head-to-tail duplications. Insertion of C-residues was noted near the origin of replication...
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