High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia
Martin Ebinger, Kai-Erik Witte, Jörg Ahlers, Iris Schäfer, Maya André, Gunter Kerst, Hans-Gerhard Scheel-Walter, Peter Lang, Rupert Handgretinger
20100801
2010 Sept 1
Leuk Res
High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia
Leuk Res. 2010 Sept;34(9):1139-1142, Martin Ebinger, Kai-Erik Witte, Jörg Ahlers, Iris Schäfer, Maya André, Gunter Kerst, Hans-Gerhard Scheel-Walter, Peter Lang, Rupert Handgretinger
Prognosis for children with acute lymphoblastic leukemia (ALL) has considerably improved, yet relapse still occurs in a significant proportion of patients. Conceivably, the most immature leukemia cells may be more resistant to therapy and initiate relapse. We studied 42 patients with childhood ALL treated according to the ALL-BFM 2000 protocol. At diagnosis, we determined the characteristic immunophenotype of the leukemic cells by flow cytometry and also investigated the expression of CD34 and CD38...
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