Differential regulation of 11β-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia
Shuji Sai, Yuichi Nakagawa, Kimiyoshi Sakaguchi, Shuichi Okada, Hiroyoshi Takahashi, Teruaki Hongo, Jonathan R. Seckl, Karen E. Chapman, Takehiko Ohzeki
20091101
2009 Dec 1
Leuk Res
Differential regulation of 11β-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia
Leuk Res. 2009 Dec;33(12):1696-1698, Shuji Sai, Yuichi Nakagawa, Kimiyoshi Sakaguchi, Shuichi Okada, Hiroyoshi Takahashi, Teruaki Hongo, Jonathan R. Seckl, Karen E. Chapman, Takehiko Ohzeki
Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) is expressed in glucocorticoid target tissue, where it regenerates active glucocorticoids from inert 11keto-glucocorticoids, amplifying intracellular glucocorticoid levels. Here, we show 11β-HSD1 expression in leukemic cells from ALL patients (n=14)....
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