Decrease of CD4+CD25+ regulatory T cells and TGF-β at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation
Qing Li, Zhimin Zhai, Xiucai Xu, Yuanyuan Shen, Aimei Zhang, Zimin Sun, Huilan Liu, Liangquan Geng, Yiping Wang
20100801
2010 Sept 1
Leuk Res
Decrease of CD4+CD25+ regulatory T cells and TGF-β at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation
Leuk Res. 2010 Sept;34(9):1158-1168, Qing Li, Zhimin Zhai, Xiucai Xu, Yuanyuan Shen, Aimei Zhang, Zimin Sun, Huilan Liu, Liangquan Geng, Yiping Wang
Graft-versus-host disease (GVHD) is a frequent and life threatening complication of allogeneic haematogenesis stem cell transplantation (aHSCT). The correlation of CD4+CD25+ regulatory T cells (Tregs) in the patients after aHSCT to the occurrence and severity of acute and chronic GVHD (aGVHD and cGVHD) is not fully investigated. Here, we examined the levels of CD4+CD25+ Tregs by assessment of CD4+CD25high and CD4+CD25+CD127low in peripheral blood, and the levels of serum TGF-β and TNF-α in 56 patients...
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