Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: Molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
Richard D. Irons, Anh Le, Liming Bao, Xiongzeng Zhu, John Ryder, Xiao Qin Wang, Meirong Ji, Yan Chen, Xichun Wu, Guowei Lin
20091101
2009 Dec 1
Leuk Res
Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: Molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
Leuk Res. 2009 Dec;33(12):1599-1603, Richard D. Irons, Anh Le, Liming Bao, Xiongzeng Zhu, John Ryder, Xiao Qin Wang, Meirong Ji, Yan Chen, Xichun Wu, Guowei Lin
ABSTRACT
The clinical, cytogenetic and molecular features of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a disease previously considered to be rare in Asia, were examined in consecutive series of 70 cases diagnosed by our laboratory over a 30-month period. Clonal abnormalities were observed in 80% of CLL/SLL cases using a combination of conventional cytogenetic and fluorescence in situ hybridization (FISH) analysis. Those involving 14q32/IGH were the most frequent (24 cases), followed...
