Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
Danka Grčević, Rajko Kušec, Nataša Kovačić, Anita Lukić, Ivan Krešimir Lukić, Sanja Ivčević, Damir Nemet, Ranka Serventi Seiwerth, Slobodanka Kolonić Ostojić, Peter I. Croucher, Ana Marušić
20100501
2010 Jun 1
Leuk Res
Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes
Leuk Res. 2010 Jun;34(6):742-751, Danka Grčević, Rajko Kušec, Nataša Kovačić, Anita Lukić, Ivan Krešimir Lukić, Sanja Ivčević, Damir Nemet, Ranka Serventi Seiwerth, Slobodanka Kolonić Ostojić, Peter I. Croucher, Ana Marušić
ABSTRACT
We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n=32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n=15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138+ plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we...
